Spyre Therapeutics, Inc.

SYRE·NasdaqGS·Healthcare
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99.04−0.23 (−0.23%)today
At close: Nov 4, 4:00 PM EST · May be delayed up to 15 min · USD

Prices may be delayed up to 15 min. Not investment advice. News volume: articles in the 4Search index each day.

Key statistics

Previous close99.27
Open99.00
Day range92.77100.00
52-week range21.15110.18
Off day high−0.96%
Off 52-week high−10.11%
Volume1.47M
Avg. volume (3M)1.21M
Market cap9.26B
EPS (TTM)-2.49
Forward P/E-27.61
P/E ratio (TTM)—
Dividend yield—
Beta (5Y)3.11
Shares outstanding93.45M
Short interest14.25% of float
Earnings dateNov 3, 2026
Analyst target122.33
Profit margin0.00%

Against its peers

Compare in full ›
SYRE 688177.SS 688382.SS ROIV ABCL PTGX
Market cap 9.26B 7.38B 8.38B 27.61B 3.98B 9.28B
P/E (TTM) — — — — — 139.2
Forward P/E -27.6 -26.2 -43.8 -27.5 -16.1 -1,444.4
Price/book 9.8 171.3 6.6 6.5 4.2 11.0
Dividend yield — — — — — —
1-year change +334.44% −34.43% −48.70% +85.85% +171.08% +80.07%
Today −0.23% +2.95% +4.33% +6.08% +0.82% +2.23%

The closest companies by business and industry (Biotechnology). Prices may be delayed up to 15 min.

Related companies

Compare ›

The businesses closest to Spyre Therapeutics's by what they do, from their descriptions, with the same industry weighted in.

Company Mkt cap Price Today
Bio-Thera Solutions, Ltd.688177.SS · Biotechnology 7.38B 17.82 +2.95%
InventisBio Co., Limited688382.SS · Biotechnology 8.38B 14.45 +4.33%
Roivant Sciences Ltd.ROIV · Biotechnology 27.61B 38.23 +6.08%
AbCellera Biologics Inc.ABCL · Biotechnology 3.98B 12.28 +0.82%
Protagonist Therapeutics, Inc.PTGX · Biotechnology 9.28B 143.37 +2.23%
Odyssey Therapeutics, Inc.ODTX · Biotechnology 937.14M 19.50 −9.60%
Keymed Biosciences Inc.2162.HK · Biotechnology 20.67B 70.150 +2.48%
Shanghai Junshi Biosciences Co., Ltd.8SJ.F · Biotechnology 1.84B 1.7900 +1.70%

Also based in Waltham, Massachusetts, then elsewhere in Massachusetts.

Company Mkt cap Price Today
Thermo Fisher Scientific Inc.TMO · Waltham, MA 261.64B 706.16 +1.12%
Veralto CorporationVLTO · Waltham, MA 28.45B 117.02 +0.60%
Revvity, Inc.RVTY · Waltham, MA 17.79B 159.43 −2.48%
Repligen CorporationRGEN · Waltham, MA 11.39B 178.20 −0.04%
Pegasystems Inc.PEGA · Waltham, MA 5.62B 34.36 +0.03%
Cogent Biosciences, Inc.COGT · Waltham, MA 5.46B 31.49 +1.38%
Crane NXT, Co.CXT · Waltham, MA 3.55B 61.62 +2.63%
Dyne Therapeutics, Inc.DYN · Waltham, MA 3.46B 18.54 +2.71%

The stocks whose daily moves over the past year went most closely with Spyre Therapeutics's: the correlation of their daily returns, where 1 would be moving as one.

Company Mkt cap Price Today
Oruka Therapeutics, Inc.ORKA · Correlation 0.50 6.71B 101.41 +1.87%
Protagonist Therapeutics, Inc.PTGX · Correlation 0.37 9.28B 143.37 +2.23%
CG Oncology, Inc.CGON · Correlation 0.37 6.00B 67.71 +5.70%
Cogent Biosciences, Inc.COGT · Correlation 0.37 5.46B 31.49 +1.38%
Dyne Therapeutics, Inc.DYN · Correlation 0.35 3.46B 18.54 +2.71%
Dianthus Therapeutics, Inc.DNTH · Correlation 0.33 4.80B 85.81 +3.76%
Cytokinetics, IncorporatedCYTK · Correlation 0.33 8.84B 63.60 +2.07%
Odyssey Therapeutics, Inc.ODTX · Correlation 0.33 937.14M 19.50 −9.60%

What visitors to Spyre Therapeutics's page also look at.

Company Mkt cap Price Today
Oruka Therapeutics, Inc.ORKA 6.71B 101.41 +1.87%
Dianthus Therapeutics, Inc.DNTH 4.80B 85.81 +3.76%
Enliven Therapeutics, Inc.ELVN 3.46B 47.25 +5.40%
CG Oncology, Inc.CGON 6.00B 67.71 +5.70%
Edgewise Therapeutics, Inc.EWTX 4.08B 37.53 −0.40%

From the 4SEARCH.business instruments index: what each company does (its business description), its industry, size, headquarters and the markets it serves; and from a year of daily prices, which move together. Prices may be delayed up to 20 min.

Latest news

All SYRE news ›
markets.businessinsider.com··2 outletsPositive

Spyre Therapeutics Announces Clinical and Preclinical Data Presentations at United European Gastroenterology Week (UEGW) 2026

Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete ... Spyre Therapeutics Announces Clinical…

SYRE
More from 1 other outlet
markets.businessinsider.com·Positive

Spyre Therapeutics initiated with a Buy at UBS

UBS initiated coverage of Spyre Therapeutics (SYRE) with a Buy rating and $120 price target The firm views Spyre as the best way to play inflam... Spyre Therapeutics initiated with a Buy at UBS UBS initiated coverage of Spyre Therapeutics…

SYRELLYJNJMRK
markets.businessinsider.com·Negative

Spyre Therapeutics falls -8.4%

Spyre Therapeutics (SYRE) is down -8.4%, or -$7.80 to $84.92. Published first on TheFly – the ultimate source for real-time, market-moving brea... Spyre Therapeutics falls -8.4% Spyre Therapeutics (SYRE) is down -8.4%, or -$7.80 to $84.92.…

SYRESGPLLYJNJ

From the 4Search news index, newest first.

In the news

38mentions in 30 days
30with it in the headline
Positivesentiment

Mentioned with

Spyre Therapeutics, Inc.36Spyre Therapeutics, Inc30Jefferies29TD Cowen26Leerink Partners20Compensation Committee17Lifesci Capital16Debt Securities11

People in the coverage

Danessa Lincoln29Sarita Garza27Tristan Rich27Stifel26Sam Semenkow22Cameron Turtle21

Themes

Healthcare33Therapeutics26Mass.21Announces18Biotechnology18Waltham16SEC Filings15Offering11

Most coverage from

  1. stocktitan.net9
  2. markets.businessinsider.com7
  3. themarketsdaily.com5
  4. manilatimes.net2
  5. marketscreener.com2

Finance and business coverage in the 4SEARCH.business news index: articles that name it in the headline, or in the text beside its ticker. Sentiment is the index's own reading of the latest 38 articles, not a forecast.

Market data is provided for information only and comes from free public sources. Prices may be delayed up to 15 minutes; data may be incomplete or inaccurate. Nothing on this page is investment advice or a recommendation to buy or sell any security. News and coverage analytics are drawn from the 4SEARCH.business index. Terms of use. How to use Finance