Septerna, Inc.

SEPN·NasdaqGM·Healthcare
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47.88+4.18 (+9.57%)today
At close: Nov 4, 4:00 PM EST · May be delayed up to 15 min · USD

Prices may be delayed up to 15 min. Not investment advice. News volume: articles in the 4Search index each day.

Key statistics

Previous close43.70
Open45.60
Day range44.7948.23
52-week range17.5551.10
Off day high−0.72%
Off 52-week high−6.30%
Volume604.66K
Avg. volume (3M)396.28K
Market cap2.23B
EPS (TTM)-0.5400
Forward P/E-24.67
P/E ratio (TTM)—
Dividend yield—
Beta (5Y)2.20
Shares outstanding46.68M
Short interest14.42% of float
Earnings dateNov 9, 2026 (est.)
Analyst target54.22
Profit margin−24.51%

Against its peers

Compare in full ›
SEPN VKTX VRDN GPCR BHVN ROIV
Market cap 2.23B 3.57B 3.29B 1.45B 2.30B 27.61B
P/E (TTM) — — — — — —
Forward P/E -24.7 -5.5 -10.7 -9.6 -8.2 -27.5
Price/book 5.7 6.1 6.8 1.1 -23.4 6.5
Dividend yield — — — — — —
1-year change +154.68% −24.95% +5.65% −39.17% +78.66% +85.85%
Today +9.57% +7.21% +15.53% +0.05% −2.37% +6.08%

The closest companies by business and industry (Biotechnology). Prices may be delayed up to 15 min.

Related companies

Compare ›

The businesses closest to Septerna's by what they do, from their descriptions, with the same industry weighted in.

Company Mkt cap Price Today
Viking Therapeutics, Inc.VKTX · BiotechnologyOdds 3.57B 27.97 +7.21%
Viridian Therapeutics, Inc.VRDN · Biotechnology 3.29B 29.06 +15.53%
Structure Therapeutics Inc.GPCR · Biotechnology 1.45B 20.36 +0.05%
Biohaven Ltd.BHVN · Biotechnology 2.30B 15.24 −2.37%
Roivant Sciences Ltd.ROIV · Biotechnology 27.61B 38.23 +6.08%
Entera Bio Ltd.ENTX · Biotechnology 540.90M 3.1100 +1.97%
Crinetics Pharmaceuticals IncCRNX · Biotechnology 9.01B 84.95 0.00%
Fortrea Holdings Inc.FTRE · Biotechnology 2.01B 20.83 −0.57%

The stocks whose daily moves over the past year went most closely with Septerna's: the correlation of their daily returns, where 1 would be moving as one.

Company Mkt cap Price Today
Immunome, Inc.IMNM · Correlation 0.38 2.30B 19.52 −3.89%
Palvella Therapeutics, Inc.PVLA · Correlation 0.37 2.34B 162.28 +6.11%
Sarepta Therapeutics, Inc.SRPT · Correlation 0.35 2.01B 18.99 +2.43%
Rigel Pharmaceuticals, Inc.RIGL · Correlation 0.34 958.09M 51.29 +4.97%
Denali Therapeutics Inc.DNLI · Correlation 0.31 3.35B 20.96 +7.76%
MBX Biosciences, Inc.MBX · Correlation 0.30 2.53B 52.48 −4.58%
Lakefront Biotherapeutics NVLKFT · Correlation 0.30 2.25B 34.09 +6.03%

What visitors to Septerna's page also look at.

Company Mkt cap Price Today
MBX Biosciences, Inc.MBX 2.53B 52.48 −4.58%
Rapport Therapeutics, Inc.RAPP 1.50B 25.93 +1.93%
Bicara Therapeutics Inc.BCAX 588.28M 8.89 −0.78%
Upstream Bio, Inc.UPB 202.65M 3.7000 +9.14%
Alumis Inc.ALMS 847.80M 6.55 +0.77%

From the 4SEARCH.business instruments index: what each company does (its business description), its industry, size, headquarters and the markets it serves; and from a year of daily prices, which move together. Prices may be delayed up to 20 min.

Latest news

All SEPN news ›
The Manila Times·Positive

Septerna to Participate in Upcoming Investor Conferences

SOUTH SAN FRANCISCO, Calif., Nov. 03, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today announced that management…

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Stock Titan·

Septerna COO Elizabeth Bhatt sells 4,000 shares

After a $6.81 option exercise, Septerna (SEPN) COO sells 4,000 shares under a preset plan. Stock Titan Septerna COO Elizabeth Bhatt sells 4,000 shares Both sales were made under a Rule 10b5-1 plan adopted October 20, 2025; the option vests…

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From the 4Search news index, newest first.

In the news

3mentions in 30 days
3with it in the headline
Positivesentiment

Mentioned with

Arcus Biosciences1Biomerica1Biontech1Black Rifle Coffee Company1Brc Inc.1Claritev Corp1Claritev Corporation1Coherus Oncology, Inc1

People in the coverage

Acacia Lorenzo Ghioni1Alan King1Amitabh Misra1Andrew Dignan1Arbutus Biopharma1Biomerica1

Themes

Healthcare210B5-1 Plan1Analyst Recommendations1Calif.1Class a Common Stock1Common Stock1Comparison1Conferences1

Most coverage from

  1. manilatimes.net1
  2. stocktitan.net1
  3. themarketsdaily.com1

Finance and business coverage in the 4SEARCH.business news index: articles that name it in the headline, or in the text beside its ticker. Sentiment is the index's own reading of the latest 3 articles, not a forecast.

Market data is provided for information only and comes from free public sources. Prices may be delayed up to 15 minutes; data may be incomplete or inaccurate. Nothing on this page is investment advice or a recommendation to buy or sell any security. News and coverage analytics are drawn from the 4SEARCH.business index. Terms of use. How to use Finance