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Discovery & Preclinical
Targets, assays, animal models, and early safety/tox studies before human trials.
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Latest in Discovery & Preclinical
This Hidden Switch In Your Body That Turns Off Inflammation
16+ hour, 21+ min ago (232+ words) Inflammation is often described as the body's alarm system, rushing immune cells to an area where there is an infection or injury. But just as important as switching inflammation on is knowing when to switch it off. Now, scientists have…...
Why does the immune system sometimes help tumors grow?
3+ day, 3+ hour ago (540+ words) Salk Institute researchers define how chronic interferon exposure prompts a switch from anti-tumor activity to immunosuppression in mice, revealing a key target to sustain anti-tumor immune responses and combat immunotherapy-resistant cancer LA JOLLA—Cancer biology and, in turn, cancer treatment…...
Existing toxicology data standards jumpstart in vivo efficacy standards
4+ day, 14+ hour ago (461+ words) Benchmarks for Natural Language Data Mining with LLMs Data FAIRy Bioassay Annotation In Vitro NAM Data Standards In Vivo Efficacy Data Standards Large Language Models in Life Sciences LLM and NLP Use Case Database MNMs for Repurposing Non Clinical In…...
Toxicity Is a Trajectory, Not a Grade
5+ day, 18+ hour ago (795+ words) One of the most overused words in oncology is "manageable". An adverse event can be clinically manageable and still change the structure of someone's life. It can be recorded as Grade 1 or Grade 2, recur across treatment cycles, erode sleep, reduce…...
Decades of data show that snakebites are not random
1+ week, 21+ hour ago (1059+ words) Global snakebite patterns are predictably correlated with a variety of environmental and socioeconomic factors. Every morning, millions of people walk into fields, tea rows and rice paddies to work, many in sandals or barefoot. A snake lying in the crop…...
The global toll of snakebite may be much bigger than we thought
1+ week, 4+ day ago (100+ words) Seventeen years after their previous global assessment, researchers used new evidence and geostatistical modeling to reveal where conventional surveillance may be missing much of the true toll of snakebite. Study: Estimates of global burden of snakebite: A literature review and…...
Could Your DNA Predict a Dangerous Drug Reaction?
1+ week, 5+ day ago (1454+ words) Scientists have identified genetic variants that make certain medications far more toxic for some people. The challenge is getting that information into the exam room As time passed, however, the side effects didn’t improve. If anything, Anderson got worse. Painful…...
Are plant based meats actually good? 212 meats tested full of fungal toxins, study reveals
2+ week, 1+ day ago (253+ words) The Times of India Of late many health enthusiasts have switched to plant based meat alternatives, but are these lab grown meat like treats actually good or do they pose some serious health concerns? Let's find outâ¦What the study…...
Targeting METTL3/m6A/SOCS3 Reprograms Macrophages, Boosting Anti-PD-1
2+ week, 2+ day ago (69+ words) Multiple myeloma may be vulnerable to an unexpected form of immune-system engineering: changing the behavior of the macrophages that surround the cancer. In a preclinical study published in Cellular and Molecular Life Sciences, researchers report that restoring a molecule called…...